|
Symbol Name ID |
Gnas
GNAS complex locus MGI:95777 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Hypocalcemic seizures |
Hypocalcemic tetany |
Decreased response to growth hormone stimulation test |
Pituitary resistance to thyroid hormone |
Basal ganglia calcification |
Choroid plexus calcification |
Myoclonic spasms |
Depression |
Emotional lability |
Irritability |
Anxiety |
Psychosis |
Agitation |
Cognitive impairment |
Mental deterioration |
Intellectual disability |
Hyporeflexia |
Dyskinesia |
Laryngeal dystonia |
Seizure |
Paresthesia |
| Disease(s) Associated with GNAS | |||||||||||||||||||||
| ACTH-independent macronodular adrenal hyperplasia 1 | |||||||||||||||||||||
| Albright's hereditary osteodystrophy | |||||||||||||||||||||
| pseudohypoparathyroidism | |||||||||||||||||||||
| pseudohypoparathyroidism type IB | |||||||||||||||||||||
| pseudopseudohypoparathyroidism |
| Mouse Phenotypes | nervous system phenotype |
abnormal sympathetic ganglion morphology |
enlarged lateral ventricles |
abnormal dorsal striatum morphology |
abnormal ventral striatum morphology |
abnormal cerebellar cortex morphology |
small dorsal root ganglion |
enhanced long-term potentiation |
decreased prepulse inhibition |
enhanced paired-pulse facilitation |
|
| Availability | Mouse Genotype | ||||||||||
| Gnastm1Lsw/Gnas+ | |||||||||||
| Gnastm2Kel/Gnas+ | * | ||||||||||
| Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-Gnas)1593Mpke/0 |
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| Gnastm5.1Lsw/Gnastm5.1Lsw H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
* | ||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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